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bold roman/italic

Even if the use in mathematical typography of bold roman to contrast
with medium italic was based on practical reasons such as
non-availability of bold italic, the extra distinctiveness seems
fortunate, especially when sub- and subsubscript uses are taken into
account. Bringhurst writes ("The Elements of Typographic Style",

  The normal function of boldface type is, after all, to contrast with
  the roman text. If the bold is used in small amounts, and bold and
  roman are not too intimately combined, a difference in structure as
  well as weight may be an asset.

Clearly substituting italic and bold italic for roman and bold roman
in the above passage describes the math situation.